A white blood cell policeman, with the help of a cold pill, must stop a deadly virus from destroying the human they live in, Frank.
Directed by Bobby Farrelly and Peter Farrelly
cold
flu
lethal virus
construction worker
Rank
#133 in 2001·#7271 overall
Trailer
IMDB
N/A
Letterboxd
3.0 / 5
Where to Watch
Cast
Chris Rock
Osmosis Jones (voice)
Laurence Fishburne
Thrax (voice)
David Hyde Pierce
Drix (voice)
Brandy Norwood
Leah (voice)
Elena Franklin
Shane Detorre
Bill Murray
Frank Detorre
William Shatner
Mayor Phlegmming (voice)
Ron Howard
Tom Colonic (voice)
Kid Rock
Kidney Rock (voice)
Molly Shannon
Mrs. Boyd
Chris Elliott
Bob
Jonathan Adams
Officer Tom (voice)
Crew
Bobby Farrelly
Director
Peter Farrelly
Director
Randy Edelman
Original Music Composer
Stephen Schaffer
Editor
Mark Irwin
Director of Photography
Bobby Farrelly
Producer
Peter Farrelly
Producer
Zak Penn
Producer
Bradley Thomas
Producer
Randy Thom
Sound Designer
Bob Camp
Storyboard
John Walker
Associate Producer
Popular Reviews
483 reviews
keniPRO
4.0★ · 04/01/26
haven’t watched a single movie in the past week so thank you to my biology teacher for making us watch this i needed it
haven’t watched a single movie in the past week so thank you to my biology teacher for making us watch this i needed it
izzy
10.0★ · 03/06/26
cant forget my roots
cant forget my roots
Kalie
8.0★ · 02/24/26
oh an absolute childhood CLASSIC that I have not seen in YEARSS!!
just as disgusting but somehow even more funny than I remember it being. I think that I definitely get a lot more of the jokes now than I did when I was a kid.
oh an absolute childhood CLASSIC that I have not seen in YEARSS!!
just as disgusting but somehow even more funny than I remember it being. I think that I definitely get a lot more of the jokes now than I did when I was a kid.
Chrisis
6.0★ · 02/13/26
Might be the grossest movie ever but at least the animation is great
Might be the grossest movie ever but at least the animation is great
Alex white
6.0★ · 02/12/26
Osmosis Jones is the genius behind the COVID vaccine
Osmosis Jones is the genius behind the COVID vaccine
