Elsa and Clive, two young rebellious scientists, defy legal and ethical boundaries and forge ahead with a dangerous experiment: splicing together human and animal DNA to create a new organism. Named "Dren", the creature rapidly develops from a deformed female infant into a beautiful but dangerous winged human-chimera, who forges a bond with both of her creators - only to have that bond turn deadly.
Directed by Vincenzo Natali
experiment
genetics
dna
gene manipulation
genetic engineering
disturbed
grim
genetically modified organism
absurd
disgusted
distressing
Rank
#199 in 2010·#8641 overall
Trailer
IMDB
N/A
Letterboxd
2.5 / 5
Where to Watch
Cast
Adrien Brody
Clive
Sarah Polley
Elsa
Delphine Chanéac
Dren
David Hewlett
Barlow
Abigail Chu
Young Dren
Stephanie Baird
Elsa / PD
Brandon McGibbon
Gavin
Amanda Brugel
Melinda Finch
Simona Măicănescu
Joan Chorot
Crew
Vincenzo Natali
Director
Vincenzo Natali
Screenplay
Cyrille Aufort
Original Music Composer
Tetsuo Nagata
Director of Photography
Steven Hoban
Producer
Guillermo del Toro
Executive Producer
Don Murphy
Executive Producer
Joel Silver
Executive Producer
Sidonie Dumas
Executive Producer
Franck Chorot
Executive Producer
David Rose
Sound Designer
John Buchan
Casting
Popular Reviews
456 reviews
vi
3.0★ · 04/17/17
there was a lot of beeping at one point and my emo ass really thought the end by my chemical romance was gonna start playing
there was a lot of beeping at one point and my emo ass really thought the end by my chemical romance was gonna start playing
3
luuk
2.0★ · 03/07/26
sorry guys ik was niet in de mood voor incestuele mutantenseks... better luck next time i guess!
sorry guys ik was niet in de mood voor incestuele mutantenseks... better luck next time i guess!
Gabrielle Hazel
1.0★ · 05/04/26
Now do you want to raise a human hybrid with me, Max ?
Now do you want to raise a human hybrid with me, Max ?
Josie
6.0★ · 04/24/26
I get what they were going for but I can't help but feel like this was poorly executed and left underexplored
I get what they were going for but I can't help but feel like this was poorly executed and left underexplored